Antimicrobial Resistance among Gram-Negative Bacteria Isolated from Different Samples of Patients Admitted to a University Hospital in Kashan, Iran

Antibiotic resistance is a complex dynamic problem, resulting in substantial morbidity, mortality and increasing cost of treatment.In this retrospective study, we examined Gram-negative bacterial resistance ofimipenem, ceftazidime and cefepime in the samplessent to the laboratory of Shahid Beheshti Hospital in 2011-2012. Data of 1041 patients were included in our study. 50.8% patients were male and 49.2% were female.79.3% of sampleswere urine, 5.6% were blood and 15.1% were from other origins. 71.9% of cultures were E coli and 9.9% were Klebsiella and 18.2% were other organisms. Resistance rates of cefepime and ceftazidime were more than 50% in most of the organisms. Imipenem had high resistance rate, comparing to other studies, but less than 50% in most cases. Gram negative bacteria weredangerously resistant to 3 wide spectrum antibiotics evaluated in this study. Making new policies towards stopping the antibiotic resistance seems to beessential.